Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia Hispanica L.)


Despite strong correlations linking whole-grain consumption to reductions in heart disease, the physiological mechanisms involved remain ambiguous. We assessed whether Salba (Salvia Hispanica L.) whole grain reduces postprandial glycemia in healthy subjects, as a possible explanation for its cardioprotective effects observed in individuals with diabetes. The study used acute, randomized, double-blind, controlled design in which 11 healthy individuals (6 males and 5 females; body mass index 22.3±2.8 kg/m2) received 0, 7, 15 or 24 g of Salba baked into white bread. Capillary samples and appetite ratings were collected over 2 h after consumption. A dose-response reduction in postprandial glycemia (P=0.002, r2=0.203) was observed with all three doses of Salba, significantly decreasing incremental areas under the curve (iAUCs) and time point-specific blood glucose (P<0.05). Appetite ratings were decreased at 60 min after high, 90 min after high and intermediate and at 120 min after all treatments (P<0.05). Decrease in postprandial glycemia provides a potential explanation for improvements in blood pressure, coagulation and inflammatory markers previously observed after 12-week Salba supplementation in type II diabetes.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout


  • Blundell JE, Rogers PJ (1991). Hunger, hedonics, and the control of satiation and satiety. In: Friedman MI, Tordoff MG, Kare MR (eds). Chemical Senses, Vol IV. Appetite and Nutrition. Marcel Dekker: New York. pp 127–148.

    Google Scholar 

  • Brouns F, Bjorck I, Frayn KN, Gibbs AL, Lang V, Slama G et al. (2005). Glycaemic index methodology. Nutr Res Rev 18, 145–171.

    Article  CAS  Google Scholar 

  • Ceriello A, Taboga C, Tonutti L, Giacomello R, Stel L, Motz E et al. (1996). Post-meal coagulation activation in diabetes mellitus: the effect of acarbose. Diabetologia 39, 469–473.

    Article  CAS  Google Scholar 

  • Chiasson JL (2006). Acarbose for the prevention of diabetes, hypertension, and cardiovascular disease in subjects with impaired glucose tolerance: the Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) Trial. Endocr Pract 12 (Suppl 1), 25–30.

    Article  Google Scholar 

  • Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M (2003). Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 290, 486–494.

    Article  CAS  Google Scholar 

  • Coutinho M, Gerstein HC, Wang Y, Yusuf S (1999). The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95 783 individuals followed for 12.4 years. Diabetes Care 22, 233–240.

    Article  CAS  Google Scholar 

  • Gentilcore D, Bryant B, Wishart JM, Morris HA, Horowitz M, Jones KL (2005). Acarbose attenuates the hypotensive response to sucrose and slows gastric emptying in the elderly. Am J Med 118, 1289.

    Article  Google Scholar 

  • Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristol JP et al. (2006). Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 295, 1681–1687.

    Article  CAS  Google Scholar 

  • O’Keefe JH, Bell DS (2007). Postprandial hyperglycemia/hyperlipidemia (postprandial dysmetabolism) is a cardiovascular risk factor. Am J Cardiol 100, 899–904.

    Article  Google Scholar 

  • O’Keefe JH, Gheewala NM, O’Keefe JO (2008). Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. J Am Coll Cardiol 51, 249–255.

    Article  Google Scholar 

  • Read N, French S, Cunningham K (1994). The role of the gut in regulating food intake in man. Nutr Rev 52, 1–10.

    Article  CAS  Google Scholar 

  • Shimabukuro M, Higa N, Chinen I, Yamakawa K, Takasu N (2006). Effects of a single administration of acarbose on postprandial glucose excursion and endothelial dysfunction in type 2 diabetic patients: a randomized crossover study. J Clin Endocrinol Metab 91, 837–842.

    Article  CAS  Google Scholar 

  • Vuksan V, Whitham D, Sievenpiper JL, Jenkins AL, Rogovik AL, Bazinet RP et al. (2007). Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trial. Diabetes Care 30, 2804–2810.

    Article  CAS  Google Scholar 

  • Wolever TM, Jenkins DJ, Jenkins AL, Josse RG (1991). The glycemic index: methodology and clinical implications. Am J Clin Nutr 54, 846–854.

    Article  CAS  Google Scholar 

Download references


Salba Smart Natural Products, Denver, CO, USA, provided Salba grain. The results were presented as an abstract at Experimental Biology 2008 (The FASEB Journal. 2008;22:305.6), supported by an unrestricted travel grant received from Salba Corporation S.A, Buenos Aires, Argentina.

Author information

Authors and Affiliations


Corresponding author

Correspondence to V Vuksan.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Vuksan, V., Jenkins, A., Dias, A. et al. Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia Hispanica L.). Eur J Clin Nutr 64, 436–438 (2010).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links