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Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects

Abstract

Objectives:

To investigate the effects of medium- and long-chain triacylglycerol (MLCT) on blood triglyceride (TG) in Chinese hypertriglyceridemic subjects.

Methods:

A double-blind controlled clinical trial was carried out, in which 112 subjects with hypertriglyceridemia were randomly divided into two dietary oil groups: (1) long-chain triacylglycerol (LCT) and (2) MLCT. All subjects were requested to ingest fixed energy and to continue their normal activity levels, and to consume LCT or MLCT oil at 25–30 g daily during the study period. Anthropometric measurements of body weight, body mass index (BMI), body fat, body fat percentage, waist and hip circumference (WC and HC), areas of subcutaneous and visceral fat by computed tomography scanning and blood biochemical markers were measured at the beginning and end of the study.

Results:

There were 50 and 51 subjects left in LCT and MLCT groups, respectively. There were no significant differences in daily intake of energy, protein, fat and carbohydrate, as well as the daily physical activity between the two groups during the study. After 8 weeks, MLCT group showed a significant decrease in body weight, BMI, WC, HC, ratio of WC and HC, body fat, body fat percentage and subcutaneous fat when compared with the initial values. The decrease in body weight, BMI, WC, body fat and subcutaneous and visceral fat was significantly greater in MLCT group than that in the LCT group. Furthermore, the serum concentrations of TG in MLCT group were significantly lower than those in the LCT group.

Conclusions:

Consumption of MLCT may reduce body weight, body fat and blood TG in hypertriglyceridemic subjects under an appropriate dietary regime.

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References

  • Alexandrou E, Herzberg GR, White MD (2007). High-level medium-chain triglyceride feeding and energy expenditure in normal-weight women. Can J Physiol Pharmacol 85, 507–513.

    Article  CAS  Google Scholar 

  • Aoyama T, Nosaka N, Kasai M (2007). Research on the nutritional characteristics of medium-chain fatty acids. J Med Invest 54, 385–388.

    Article  Google Scholar 

  • Ascaso J, Gonzalez Santos P, Hernandez Mijares A, Mangas Rojas A, Masana L, Millan J et al. (2007). Management of dyslipidemia in the metabolic syndrome: recommendations of the Spanish HDL-Forum. Am J Cardiovasc Drugs 7, 39–58.

    Article  CAS  Google Scholar 

  • Bach AC, Babayan VK (1982). Medium-chain triglycerides: an update. Am J Clin Nutr 36, 950–962.

    Article  CAS  Google Scholar 

  • Barness LA, Opitz JM, Gilbert-Barness E (2007). Obesity: genetic, molecular, and environmental aspects. Am J Med Genet A 143, 3016–3034.

    Article  Google Scholar 

  • Betteridge DJ (2000). Diabetic dyslipidaemia. Diabetes Obes Metab 2 (Suppl 1), S31–S36.

    Article  CAS  Google Scholar 

  • Calabrese C, Myer S, Munson S, Turet P, Birdsall TC (1999). A cross-over study of the effect of a single oral feeding of medium chain triglyceride oil vs. canola oil on post-ingestion plasma triglyceride levels in healthy men. Altern Med Rev 4, 23–28.

    CAS  PubMed  Google Scholar 

  • Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) (2001). Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285, 2486–2497.

    Article  Google Scholar 

  • Glisic S, Arrigo P, Alavantic D, Perovic V, Prljic J, Veljkovic N (2007). Lipoprotein lipase: a bioinformatics criterion for assessment of mutations as a risk factor for cardiovascular disease. Proteins 70, 855–862.

    Article  Google Scholar 

  • Hill JO, Peters JC, Swift LL, Yang D, Sharp T, Abumrad N et al. (1990). Changes in blood lipids during six days of overfeeding with medium or long chain triglycerides. J Lipid Res 31, 407–416.

    CAS  PubMed  Google Scholar 

  • Kasai M, Maki H, Nosaka N, Aoyama T, Ooyama K, Uto H et al. (2003a). Effect of medium-chain triglycerides on the postprandial triglyceride concentration in healthy men. Biosci Biotechnol Biochem 67, 46–53.

    Article  CAS  Google Scholar 

  • Kasai M, Nosaka N, Maki H, Negishi S, Aoyama T, Nakamura M et al. (2003b). Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans. Asia Pac J Clin Nutr 12, 151–160.

    CAS  PubMed  Google Scholar 

  • Kolovou GD, Anagnostopoulou KK, Cokkinos DV (2005). Pathophysiology of dyslipidaemia in the metabolic syndrome. Postgrad Med J 81, 358–366.

    Article  CAS  Google Scholar 

  • Krentz AJ (2003). Lipoprotein abnormalities and their consequences for patients with type 2 diabetes. Diabetes Obes Metab 5 (Suppl 1), S19–S27.

    Article  CAS  Google Scholar 

  • Le NA, Walter MF (2007). The role of hypertriglyceridemia in atherosclerosis. Curr Atheroscler Rep 9, 110–115.

    Article  CAS  Google Scholar 

  • Matsuo T, Takeuchi H (2004). Effects of structured medium- and long-chain triacylglycerols in diets with various levels of fat on body fat accumulation in rats. Br J Nutr 91, 219–225.

    Article  CAS  Google Scholar 

  • Matsuo T, Matsuo M, Kasai M, Takeuchi H (2001). Effects of a liquid diet supplement containing structured medium- and long-chain triacylglycerols on bodyfat accumulation in healthy young subjects. Asia Pac J Clin Nutr 10, 46–50.

    Article  CAS  Google Scholar 

  • Noguchi O, Takeuchi H, Kubota F, Tsuji H, Aoyama T (2002). Larger diet-induced thermogenesis and less body fat accumulation in rats fed medium-chain triacylglycerols than in those fed long-chain triacylglycerols. J Nutr Sci Vitaminol (Tokyo) 48, 524–529.

    Article  CAS  Google Scholar 

  • Nosaka N, Kasai M, Nakamura M, Takahashi I, Itakura M, Takeuchi H et al. (2002). Effects of dietary medium-chain triacylglycerols on serum lipoproteins and biochemical parameters in healthy men. Biosci Biotechnol Biochem 66, 1713–1718.

    Article  CAS  Google Scholar 

  • Nosaka N, Maki H, Suzuki Y, Haruna H, Ohara A, Kasai M et al. (2003). Effects of margarine containing medium-chain triacylglycerols on body fat reduction in humans. J Atheroscler Thromb 10, 290–298.

    Article  CAS  Google Scholar 

  • Ogawa A, Nosaka N, Kasai M, Aoyama T, Okazaki M, Igarashi O et al. (2007). Dietary medium- and long-chain triacylglycerols accelerate diet-induced thermogenesis in humans. J Oleo Sci 56, 283–287.

    Article  CAS  Google Scholar 

  • Roynette CE, Rudkowska I, Nakhasi DK, Jones PJ (2008). Structured medium and long chain triglycerides show short-term increases in fat oxidation, but no changes in adiposity in men. Nutr Metab Cardiovasc Dis 18, 298–305.

    Article  CAS  Google Scholar 

  • Shinohara H, Wu J, Kasai M, Aoyama T (2006). Randomly interesterified triacylglycerol containing medium- and long-chain fatty acids stimulates fatty acid metabolism in white adipose tissue of rats. Biosci Biotechnol Biochem 70, 2919–2926.

    Article  CAS  Google Scholar 

  • St-Onge MP, Jones PJ (2002). Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr 132, 329–332.

    Article  CAS  Google Scholar 

  • St-Onge MP, Jones PJ (2003). Greater rise in fat oxidation with medium-chain triglyceride consumption relative to long-chain triglyceride is associated with lower initial body weight and greater loss of subcutaneous adipose tissue. Int J Obes Relat Metab Disord 27, 1565–1571.

    Article  CAS  Google Scholar 

  • St-Onge MP, Bourque C, Jones PJ, Ross R, Parsons WE (2003a). Medium- versus long-chain triglycerides for 27 days increases fat oxidation and energy expenditure without resulting in changes in body composition in overweight women. Int J Obes Relat Metab Disord 27, 95–102.

    Article  CAS  Google Scholar 

  • St-Onge MP, Ross R, Parsons WD, Jones PJ (2003b). Medium-chain triglycerides increase energy expenditure and decrease adiposity in overweight men. Obes Res 11, 395–402.

    Article  CAS  Google Scholar 

  • Takeuchi H, Kasai M, Taguchi N, Tsuji H, Suzuki M (2002). Effect of triacylglycerols containing medium- and long-chain fatty acids on serum triacylglycerol levels and body fat in college athletes. J Nutr Sci Vitaminol (Tokyo) 48, 109–114.

    Article  CAS  Google Scholar 

  • Tokunaga K, Matsuzawa Y, Ishikawa K, Tarui S (1983). A novel technique for the determination of body fat by computed tomography. Int J Obes 7, 437–445.

    CAS  Google Scholar 

  • Tsuji H, Kasai M, Takeuchi H, Nakamura M, Okazaki M, Kondo K (2001). Dietary medium-chain triacylglycerols suppress accumulation of body fat in a double-blind, controlled trial in healthy men and women. J Nutr 131, 2853–2859.

    Article  CAS  Google Scholar 

  • Yost TJ, Eckel RH (1989). Hypocaloric feeding in obese women: metabolic effects of medium-chain triglyceride substitution. Am J Clin Nutr 49, 326–330.

    Article  CAS  Google Scholar 

  • Yuan G, Al-Shali KZ, Hegele RA (2007). Hypertriglyceridemia: its etiology, effects and treatment. CMAJ 176, 1113–1120.

    Article  Google Scholar 

Download references

Acknowledgements

We are grateful for the support provided by Dr Akira Seto and Ms Kaori Nakajima. We also gratefully acknowledge the dedicated volunteers who participated in this project.

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Correspondence to J Wu.

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Xue, C., Liu, Y., Wang, J. et al. Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in Chinese hypertriglyceridemic subjects. Eur J Clin Nutr 63, 879–886 (2009). https://doi.org/10.1038/ejcn.2008.76

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  • DOI: https://doi.org/10.1038/ejcn.2008.76

Keywords

  • medium- and long-chain triacylglycerol
  • body fat
  • blood triglyceride
  • hypertriglyceridemia
  • Chinese

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