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How do mice remember pheromone locations?

Research suggests that mice can use multiple sensory systems to remember pheromone-dependent socio-sexual cues.Credit: Getty Images

How do mice remember the locations of pheromone-streaked stones, burrows and fallen leaves, even days after encountering them?

Researchers at the Indian Institute of Science Education and Research in Pune, India, have deciphered the underlying process of such memory formation. They studied female mice which were repeatedly exposed to the pheromone-laden urine of male mice and observed that the female mice were able to remember the locations and shapes of objects where they sampled the pheromones1.

The mice sniffed and used their whiskers to sense the pheromones. These cues were then sent to specific brain regions involved in learning and memorising pheromone locations.

Their findings suggest that mice can use multiple sensory systems to remember pheromone-dependent socio-sexual cues, the researchers say.

The researchers, led by Nixon M Abraham, trained female mice to learn to associate certain shapes and sizes of orifices with pheromonal cues.

They found that the mice remembered the pheromone locations two weeks after their initial exposure.

When the whiskers were removed from one group of female mice they failed to form a pheromone memory despite having a sense of smell. And female mice with whiskers failed to form a pheromone memory when they were exposed to same-sex urine.

The researchers traced the roots of such memory to an increased number of neurons in specific brain regions. These were identified by tracking a marker called activity-regulated cytoskeleton-associated protein in the whisker-intact mice.

doi: https://doi.org/10.1038/d44151-021-00064-4

References

  1. 1.

    Pardasani, M. et al. FASEB. J. 35, e21836 (2021)

    PubMed  Article  Google Scholar 

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