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A nano-hospital in every body

Nanoscale doctors curing the body from within sounds like science fiction, but for Japanese research centre COINS, it’s a serious goal.

The ambition is grand and the timeline spans decades: the development of nanomachines dispersed in the human body, performing detection, diagnosis and treatment and communicating wirelessly with physicians who monitor and direct treatment.

Nanomachines may one day patrol inside the body and carry out treatment from within.

“In the future, you will have a whole hospital in your body,” says Professor Kazunori Kataoka, director-general of the Innovation Center of NanoMedicine. “The medical and diagnostic instruments, all working as nanomachines. It’s a concept we call the ‘in-body hospitals’. It isn’t a dream. We think this kind of system will be accomplished by 2045.

“You might have nanomachines made from organic compounds which circulate in your blood, accumulate at disease sites, such as cancer, and treat it. Or a nanomachine will capture chemical information from a disease site and bring it to an implanted chip, where analysis is carried out, and this information is transmitted to doctors outside the body.”

COINS Project Leader Hiromichi Kimura and COINS Research Leader and Director-General, Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion, Kazunori Kataoka.

Professor Kataoka is a giant in the world of biomedicine and polymer chemistry; he is the man who developed polymer micelle nanocarriers for targeted drug and gene delivery. The work is now close to being applied in cancer therapy and in 1996 it spawned NanoCarrier, a ¥24 billion company that is spearheading seven nanotech treatments for a host of cancers, including those of the pancreas, lung, breast, stomach, head and neck.

He sees the ‘in-body hospitals’ as a moonshot, a vision that can drive a flurry of advances in nanomedicine. It’s the primary mission of an R&D effort known as COINS, or Center of Open Innovation Network for Smart Health. COINS unites medical researchers, engineers and clinicians from five universities, seven government institutes, and 14 companies, among them global imaging leaders Fujifilm and chemical manufacturers JSR and NOF. The COINS research collaboration is both led by and is housed in the Innovation Center of NanoMedicine (iCONM), which opened in 2015. Under the one roof, iCONM co-locates six COINS laboratories along with five other laboratories and microfabrication facilities adjacent to Tokyo International Airport (Haneda).

“iCONM is designed like a big apartment complex with a concierge, aggregating multiple functions in one building,” says Professor Kataoka. “Each floor has its own function: the first has micromachining facilities and clean rooms, the second has facilities for material evaluation and organic synthesis, the third has laboratories for cell and genetic experiments, and the fourth has animal labs. Since these facilities follow different regulations, it is actually quite rare to have them concentrated in one building like this.”

iCONM, Kawasaki’s pride aiming to be the world’s most innovative hub

iCONM is located in a new 40-hectare innovation hub known as the KING SKYFRONT (Kawasaki INnovation Gateway at SKYFRONT), where more than 60 companies base their research operations alongside those from scores of universities, hospitals and government research institutes. The KING SKYFRONT is one of Japan’s 10 National Strategic Special Zones, where local government offers incentives to industry and the national government loosens laws and regulations to help boost innovation.

COINS is itself one of the five major industry-academia collaborations – known as the Center of Innovation (COI) program – funded by the Japanese Science and Technology Agency (JST), and Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) to accelerate advances in human health, or what it calls ‘smart life care in an ageless society’. And human health itself is just one of the three core visions funded under the COI program — the others being quality of life and active sustainability — which are all aimed at creating a future Japan where nanotechnology, robotics, artificial intelligence and big data work seamlessly across government, industry and civil society to create both economic development and solutions to social problems.

It’s a tall order, but it’s one the Japanese government has committed to, dubbing it ‘Society 5.0’ — a convergence between the virtual and physical worlds — to solve the economic and social challenges of Japan’s rapidly ageing population and stagnant growth.

Total Japanese government R&D investment from 2016 to 2020 — about US$228 billion — has often been structured around the ‘Society 5.0’ objective. And it’s understandable why: by 2065, 40% of Japan’s population will be older than 65. Innovation will be needed to not only extend working lives and improve well-being, but also reduce the cost of healthcare. In doing this, Japan hopes to create a plethora of new technologies and industries that will revitalize economic growth.

In this task, the ‘in-body hospitals’ moonshot will necessarily play a major part, says Professor Kataoka: “Since it would be difficult to introduce all manner of devices into a healthy human body, we will open the way to realize this concept by first using nanotechnology to diagnose and treat diseases, or offer faster, affordable treatment that would not require hospitalization.”

As a high school student in the 1960s, Professor Kataoka saw the film Fantastic Voyage, in which a submarine with a crew of physicians is miniaturized to the nanoscale and injected the body of a man to remove a blood clot in his brain. “It left a strong impression,” he recalls. “Now here we are, making it a reality.”

doi: 10.1038/d42473-018-00257-z