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First step to cell therapy for ischemic stroke in newborns
In a first-in-human study, intranasal transplantation of mesenchymal stromal cells was safe and well-tolerated in newborns who had suffered a stroke — laying the foundation for large-scale clinical trials.
Perinatal arterial ischemic stroke (PAIS) is rare but can cause lifelong neurodevelopmental disabilities. Currently, the only available treatment is supportive care, which has no protective or regenerative effects.