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  • RESEARCH BRIEFINGS

How a bacterial immune system gets taken apart

Investigating small protein inhibitors of CRISPR–Cas — an adaptive immune system in bacteria — has led to the discovery of a mechanism for inhibiting a large macromolecular complex. AcrIF25, an anti-CRISPR protein, blocks CRISPR–Cas activity by sequentially extracting all six Cas7 subunits from this complex.

This is a summary of: Trost, C. N. et al. An anti-CRISPR that pulls apart a CRISPR–Cas complex. Nature 632, 375–382 (2024).

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doi: https://doi.org/10.1038/d41586-024-02816-5

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