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Childhood leukaemia in Down’s syndrome primed by blood-cell bias

An in-depth investigation of gene regulation and cell populations at sites of fetal blood-cell production provides clues as to why children with Down’s syndrome are predisposed to developing leukaemia.
  1. Sébastien Malinge

    1. Sébastien Malinge is at The Kids Research Institute Australia (Cancer Centre), Perth Children’s Hospital, Nedlands, Western Australia 6009, Australia.

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Around one in 1,000 individuals is born with Down’s syndrome, a condition characterized by an extra copy of chromosome 21 (trisomy 21). Writing in Nature, Marderstein et al.1 examine the cellular and molecular features that predispose children with Down’s syndrome to a type of blood cancer called leukaemia.

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Nature 634, 40-42 (2024)

doi: https://doi.org/10.1038/d41586-024-02785-9

References

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Competing Interests

The author declares no competing interests.

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