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  • RESEARCH BRIEFINGS

How migrating cells define their back to move forward

Migrating cells must determine where to form a front end and a back end. A gradient in contact sites between the cell membrane and an organelle called the endoplasmic reticulum (ER) is generated by a gradient of ER curvature and is required to guide and control migration speed.

This is a summary of: Gong, B. et al. Endoplasmic reticulum–plasma membrane contact gradients direct cell migration. Nature 631, 415–423 (2024).

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doi: https://doi.org/10.1038/d41586-024-02572-6

Figure 1 is published under a CC BY 4.0 licence.

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