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Lipids act as structural components of the pore of an ion-channel family

Structural, functional and computational evidence demonstrates that when certain ion channels are activated by mechanical force, they assume an open configuration in which the pore is formed by both protein and lipids.

This is a summary of: Han, Y. et al. Mechanical activation opens a lipid-lined pore in OSCA ion channels. Nature 628, 910–918 (2024).

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doi: https://doi.org/10.1038/d41586-024-02477-4

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