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Structures of the dopamine transporter point to ways to target addiction and disease

Three studies of the human dopamine transporter reveal how it binds to molecules such as dopamine and cocaine. Dopamine imbalances underlie some brain conditions and these data will aid targeted drug design.
  1. Harald H. Sitte

    1. Harald H. Sitte is at the Center of Physiology and Pharmacology, Institute of Pharmacology, Medical University of Vienna, Vienna 1090, Austria.

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Dopamine is a key neurotransmitter molecule that cells called dopaminergic neurons use to signal to each other across synapses — the interfaces between these cells. Writing in Nature, Srivastava et al.1, Nielsen et al.2 and Li et al.3 provide exciting structural insights into how a variety of molecules bind to the human dopamine transporter (DAT). The papers, which gathered evidence using a technique called cryo-electron microscopy, are consistent with each other regarding many aspects of the structures. These studies mark a key turning point for the development of targeted drugs to treat DAT-related conditions.

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Nature 632, 509-511 (2024)

doi: https://doi.org/10.1038/d41586-024-02435-0

References

  1. Srivastava, D. K. et al. Nature 632, 672–677 (2024).

    Article  Google Scholar 

  2. Nielsen, J. C. et al. Nature 632, 678–685 (2024).

    Article  Google Scholar 

  3. Li, Y. et al. Nature 632, 686–694 (2024).

    Article  Google Scholar 

  4. Kristensen, A. S. et al. Pharmacol. Rev. 63, 585–640 (2011).

    Article  PubMed  Google Scholar 

  5. Yamashita, A., Singh, S. K., Kawate, T., Jin, Y. & Gouaux, E. Nature 437, 215–223 (2005).

    Article  PubMed  Google Scholar 

  6. Coleman, J. A., Green, E. M. & Gouaux, E. Nature 532, 334–339 (2016).

    Article  PubMed  Google Scholar 

  7. Zhang, H. et al. Nature 630, 247–254 (2024).

    Article  PubMed  Google Scholar 

  8. Tan, J. et al. Nature https://doi.org/10.1038/s41586-024-07719-z (2024).

    Article  Google Scholar 

  9. Penmatsa, A., Wang, K. H. & Gouaux, E. Nature 503, 85–90 (2013).

    Article  PubMed  Google Scholar 

  10. Niello, M., Gradisch, R., Loland, C. J., Stockner, T. & Sitte, H. H. Trends Pharmacol. Sci. 41, 446–463 (2020).

    Article  PubMed  Google Scholar 

  11. Jardetzky, O. Nature 211, 969– 970 (1966).

    Article  PubMed  Google Scholar 

  12. Chen, N., Zhen, J. & Reith, M. E. A. J. Neurochem. 89, 853–864 (2004).

    Article  PubMed  Google Scholar 

  13. Niello, M. et al. Proc. Natl Acad. Sci. USA 120, e2114204120 (2023).

    Article  PubMed  Google Scholar 

  14. Newman, A. H., Ku, T., Jordan, C. J., Bonifazi, A. & Xi, Z.-X. Annu. Rev. Pharmacol. Toxicol. 61, 609–628 (2021).

    Article  PubMed  Google Scholar 

  15. Norregaard, L., Frederiksen, D., Nielsen, E. Ø. & Gether, U. EMBO J. 17, 4266–4273 (1998).

    Article  PubMed  Google Scholar 

  16. Herborg, F. et al. JCI Insight 6, e151496 (2021).

    Article  PubMed  Google Scholar 

  17. Holton, K. L, Loder, M. K. & Melikian, H. E. Nature Neurosci. 8, 881–888 (2005).

    Article  PubMed  Google Scholar 

  18. Sulzer, D. Neuron 69, 628–649 (2011).

    Article  PubMed  Google Scholar 

  19. Belovich, A. N. et al. Mol. Psychiatry 26, 4417–4430 (2021).

    Article  PubMed  Google Scholar 

  20. Mackie, P. et al. Brain Behav. Immun. 70, 21–35 (2018).

    Article  PubMed  Google Scholar 

Download references

Competing Interests

The author declares no competing interests.

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