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‘It’s all gone’: CAR-T therapy forces autoimmune diseases into remission

Engineered immune cells, most commonly used to treat cancers, show their power against lupus and other immune disorders.
  1. Heidi Ledford
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Engineered immune cells have given 15 people with once-debilitating autoimmune disorders a new lease on life, free from fresh symptoms or treatments. The results raise hopes that the approach — called CAR-T-cell therapy — might one day be extended to a variety of other conditions fuelled by rogue immune cells that produce antibodies against the body’s own tissues.

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Nature 624, 483-484 (2023)

doi: https://doi.org/10.1038/d41586-023-03968-6

References

  1. Kansal, R. et al. Sci. Transl. Med. 11, eaav1648 (2019).

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  2. Haghikia, A. et al. Lancet Neurol. 22, 1104–1105 (2023).

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