Diabetes prevention programme put to the test

Gregg, Edward W.; Holman, Naomi

doi:10.1038/d41586-023-03431-6

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15 November 2023

Diabetes prevention programme put to the test

Causal evidence shows that referring people who are at risk of developing diabetes to a nationwide lifestyle-change programme can result in health improvements — but only if programme participation can be sustained.

Edward W. Gregg⁰ &
Naomi Holman¹

Edward W. Gregg
1. Edward W. Gregg is in the School of Population Health, RCSI University of Medicine and Health Sciences, Dublin D02 DH60, Ireland, and the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
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Naomi Holman
1. Naomi Holman is in the School of Population Health, RCSI University of Medicine and Health Sciences, Dublin D02 DH60, Ireland, and the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
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For the past seven years, England has taken one of the world’s boldest approaches to the prevention of type 2 diabetes. The National Health Service Diabetes Prevention Programme (NHS DPP) is a community-based, structured lifestyle programme, which offers at least 13 sessions to participants. The programme is designed to help adults at high risk of developing diabetes to improve their diet, increase their physical activity and attain a healthy weight¹. Writing in Nature, Lemp et al.² report a multi-faceted analysis that evaluates how impactful this kind of large-scale intervention really is.

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doi: https://doi.org/10.1038/d41586-023-03431-6

References

Valabhji, J. et al. Diabetes Care 43, 152–160 (2020).
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Lemp, J. M. et al. Nature https://doi.org/10.1038/s41586-023-06756-4 (2023).
Article Google Scholar
Knowler, W. C. et al. N. Engl. J. Med. 346, 393–403 (2002).
Article PubMed Google Scholar
Jonas, D. E. et al. JAMA 326, 744–760 (2021).
Article PubMed Google Scholar
Wing, R. R. & The Look AHEAD Research Group Obesity 29, 1246–1258 (2021).
Article Google Scholar
Wareham, N. J. Lancet Diabetes Endocrinol. 3, 160–161 (2015).
Article PubMed Google Scholar
Ali, M. K., Echouffo-Tcheugui, J. B. & Williamson, D. F. Health Aff. 31, 67–75 (2012).
Article Google Scholar
Sun, H. et al. Diabetes Res. Clin. Pract. 183, 109119 (2022).
Article PubMed Google Scholar
Ely, E. K. et al. Diabetes Care 40, 1331–1341 (2017).
Article PubMed Google Scholar
Mudaliar, U. et al. PLoS Med. 13, e1002095 (2016).
Article PubMed Google Scholar
Cook, T. D. J. Econometrics 142, 636–654 (2008).
Article Google Scholar
Spratt, S. E. et al. J. Am. Med. Infor. Assoc. 24, e121–e128 (2017).
Article Google Scholar
Bellou, V., Belbasis, L., Tzoulaki, I. & Evangelou, E. PLoS ONE 13, e0194127 (2018).
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Lingvay, I., Sumithran, P., Cohen, R. V. & le Roux, C. W. Lancet 399, 394–405 (2022).
Article PubMed Google Scholar
Pittas, A. G. et al. Ann. Intern. Med. 176, 355–363 (2023).
Article PubMed Google Scholar
Gregg, E. W. et al. Diabetes Care 46, 1316–1326 (2023).
Article PubMed Google Scholar

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The authors declare no competing interests.

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[1] Valabhji, J. et al. Diabetes Care 43, 152–160 (2020).
Article PubMed Google Scholar

[2] Lemp, J. M. et al. Nature https://doi.org/10.1038/s41586-023-06756-4 (2023).
Article Google Scholar

[3] Knowler, W. C. et al. N. Engl. J. Med. 346, 393–403 (2002).
Article PubMed Google Scholar

[4] Jonas, D. E. et al. JAMA 326, 744–760 (2021).
Article PubMed Google Scholar

[5] Wing, R. R. & The Look AHEAD Research Group Obesity 29, 1246–1258 (2021).
Article Google Scholar

[6] Wareham, N. J. Lancet Diabetes Endocrinol. 3, 160–161 (2015).
Article PubMed Google Scholar

[7] Ali, M. K., Echouffo-Tcheugui, J. B. & Williamson, D. F. Health Aff. 31, 67–75 (2012).
Article Google Scholar

[8] Sun, H. et al. Diabetes Res. Clin. Pract. 183, 109119 (2022).
Article PubMed Google Scholar

[9] Ely, E. K. et al. Diabetes Care 40, 1331–1341 (2017).
Article PubMed Google Scholar

[10] Mudaliar, U. et al. PLoS Med. 13, e1002095 (2016).
Article PubMed Google Scholar

[11] Cook, T. D. J. Econometrics 142, 636–654 (2008).
Article Google Scholar

[12] Spratt, S. E. et al. J. Am. Med. Infor. Assoc. 24, e121–e128 (2017).
Article Google Scholar

[13] Bellou, V., Belbasis, L., Tzoulaki, I. & Evangelou, E. PLoS ONE 13, e0194127 (2018).
Article PubMed Google Scholar

[14] Lingvay, I., Sumithran, P., Cohen, R. V. & le Roux, C. W. Lancet 399, 394–405 (2022).
Article PubMed Google Scholar

[15] Pittas, A. G. et al. Ann. Intern. Med. 176, 355–363 (2023).
Article PubMed Google Scholar

[16] Gregg, E. W. et al. Diabetes Care 46, 1316–1326 (2023).
Article PubMed Google Scholar

Diabetes prevention programme put to the test

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TENURE TRACK ASSISTANT PROFESSOR in microbial interactions

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