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Anti-ageing molecule boosts fertility in ageing mice

‘Undeniably groundbreaking’ work shows that declining egg quality in older mice can be reversed with a dietary supplement.
  1. Gemma Conroy
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A stained semi-thin section of mouse ovary to show a maturing Graafian follicle, complete with primary oocyte.

Follicles — the structures that hold developing egg cells — degenerate with age. Credit: M. I. Walker/Science Photo Library

Declining fertility in older mice has been reversed by giving the animals a compound already found in most living cells. The process also causes them to produce larger litters. The findings, published today in Nature Aging1, offer clues that could aid the development of treatments for humans with fertility issues.

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doi: https://doi.org/10.1038/d41586-023-03224-x

References

  1. Zhang, Y. et al. Nature Aging https://doi.org/10.1038/s43587-023-00498-8 (2023).

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