Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • COMMENT

AI can help to speed up drug discovery — but only if we give it the right data

Wide low-angle view of a white robotic arm on a table, surrounded by glass

Leaps in technology are supporting AI-guided drug design, such as this fully robotic workstation that can purify proteins and move liquids. Credit: Daniel Yoo

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Nature 621, 467-470 (2023)

doi: https://doi.org/10.1038/d41586-023-02896-9

References

  1. Thomas, D. et al. Clinical Development Success Rates and Contributing Factors 2011–2020 (BIO, QLS & Informa, 2021).

    Google Scholar 

  2. Fernando, K. et al. Drug Discov. Today 27, 697–704 (2022).

    Article  PubMed  Google Scholar 

  3. Reck, M. et al. J. Clin. Oncol. 39, 2339–2349 (2021).

    Article  PubMed  Google Scholar 

  4. Deshaies, R. J. Nature 580, 329–338 (2020).

    Article  PubMed  Google Scholar 

  5. Mak, K.-K. & Pichika, M. R. Drug Discov. Today 24, 773–780 (2019).

    Article  PubMed  Google Scholar 

  6. Rieke, N. et al. NPJ Digit. Med. 3, 119 (2020).

    Article  PubMed  Google Scholar 

  7. Raybould, M. I. J. et al. Proc. Natl Acad. Sci. USA 116, 4025–4030 (2019).

    Article  PubMed  Google Scholar 

  8. Jain, T. et al. Proc. Natl Acad. Sci. USA 114, 944–949 (2017).

    Article  PubMed  Google Scholar 

  9. Heyndrickx, W. et al. Preprint at ChemRxiv https://doi.org/10.26434/chemrxiv-2022-ntd3r (2022).

  10. Bailey, M. et al. Preprint at bioRxiv https://doi.org/10.1101/2023.07.26.550653 (2023).

  11. Olsen, T. H., Boyles, F. & Deane, C. M. Protein Sci. 31, 141–146 (2022).

    Article  PubMed  Google Scholar 

Download references

Competing Interests

All co-authors are employees and stockholders of Amgen, Inc.

Subjects

Latest on:

Nature Careers

Jobs

  • High-Level Talents at the First Affiliated Hospital of Nanchang University

    For clinical medicine and basic medicine; basic research of emerging inter-disciplines and medical big data.

    Nanchang, Jiangxi, China

    The First Affiliated Hospital of Nanchang University

  • Associate or Senior Editor, Nature Electronics

    Job Title: Associate or Senior Editor, Nature Electronics   Location: New York, Shanghai or Beijing — Hybrid Working   Closing date for application...

    New York City, New York (US)

    Springer Nature Ltd

  • Postdoctoral Fellow

    To study how a population of skeletal stem cells mediate bone regeneration and orchestrate a composite tissue regeneration program using mouse models.

    Hospital for Special Surgery, New York City, New York (US)

    Hospital for Special Surgery

  • Lecturer / Associate Professor in Advanced Cell Models

    Lecturer / Associate Professor in Advanced Cell Models Cell and Developmental Biology Location: Highfield Campus Salary: £44,263 to £72,018 per ann...

    Southampton, Hampshire (GB)

    University of Southampton

  • Lecturer / Associate Professor in Biological Sciences

    Lecturer / Associate Professor in Biological Sciences School of Biological Sciences Location: Highfield Campus Salary: £44,263 to £72,018 per annum...

    Southampton, Hampshire (GB)

    University of Southampton

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Quick links