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Super-precise CRISPR tool enters US clinical trials for the first time

Base editing, which makes specific changes to a cell’s genome, is put to the test in CAR-T-cell treatments for leukaemia.
  1. Heidi Ledford
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A high-precision successor to CRISPR genome editing has reached a milestone: the technique, called base editing, has made its US debut in a clinical trial. The trial tests more complex genome edits than those performed in humans so far.

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Nature 621, 667-668 (2023)

doi: https://doi.org/10.1038/d41586-023-02836-7

References

  1. Chiesa, R. et al. N. Engl. J. Med. 389, 899–910 (2023).

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  2. Fiumara, M. et al. Nature Biotechnol. https://doi.org/10.1038/s41587-023-01915-4 (2023).

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