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Anti-ageing protein injection boosts monkeys’ memories
Injecting ageing monkeys with a ‘longevity factor’ protein can improve their cognitive function, a study reveals.
The findings, published on 3 July in Nature Aging1, could lead to new treatments for neurodegenerative diseases.
It is the first time that restoring levels of klotho — a naturally occurring protein that declines in our bodies with age — has been shown to improve cognition in a primate. Previous research on mice had shown that injections of klotho can extend the animals’ lives and increases synaptic plasticity2 — the capacity to control communication between neurons, at junctions called synapses.
“Given the close genetic and physiological parallels between primates and humans, this could suggest potential applications for treating human cognitive disorders,” says Marc Busche, a neurologist at the UK Dementia Research Institute group at University College London.
The protein is named after the Greek goddess Clotho, one of the Fates, who spins the thread of life.
Monkey memory tests
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Nature 619, 234 (2023)
doi: https://doi.org/10.1038/d41586-023-02214-3
References
Castner, S. A. et al. Nature Aging https://doi.org/10.1038/s43587-023-00441-x (2023).
Dubal, D. B. et al. J. Neurosci. 35, 2358–2371 (2015).
Grøntvedt, G. R. et al. JAMA Netw. Open 5, e2243232 (2022).
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