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  • RESEARCH HIGHLIGHT

A CRISPR-based method makes T cells that thwart teens’ cancer

A technique called base editing has been used for the first time to treat human disease.
T Lymphocyte, coloured scanning electron micrograph (SEM).

T cells (pictured, artificially coloured) can be engineered to fight abnormal T cells that are a feature of an aggressive form of leukaemia. Credit: David Scharf/SPL

In a first, scientists have used a DNA-altering method called base editing to treat disease — in this case, by modifying immune cells to successfully treat two teenagers with an aggressive form of childhood leukaemia1.

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Nature 618, 889 (2023)

doi: https://doi.org/10.1038/d41586-023-01945-7

References

  1. Chiesa, R. et al. N. Engl. J. Med. https://www.nejm.org/doi/10.1056/NEJMoa2300709 (2023).

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