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  • RESEARCH BRIEFINGS

Insights into the genetic architecture of multiple sclerosis severity

Multiple sclerosis is an autoimmune disease of the central nervous system and a common cause of chronic neurological disability in young adults. A systematic search identifies genetic variants associated with differences in severity and confirms resilience of the central nervous system to be an important determinant of outcome.

This is a summary of: International Multiple Sclerosis Genetics Consortium & MultipleMS Consortium. Locus for severity implicates CNS resilience in progression of multiple sclerosis. Nature https://doi.org/10.1038/s41586-023-06250-x (2023).

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doi: https://doi.org/10.1038/d41586-023-01787-3

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