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A tool for optimizing messenger RNA sequence

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Nature 621, 262-264 (2023)



  1. Rubin, E. J. & Longo, D. L. N. Engl. J. Med. 386, 183–185 (2022).

    Article  PubMed  Google Scholar 

  2. Zhang, H. et al. Nature 621, 396–403 (2023).

    Article  Google Scholar 

  3. Leppek, K. et al. Nature Commun. 13, 1536 (2022).

    Article  PubMed  Google Scholar 

  4. Leppek, K., Das, R. & Barna, M. Nature Rev. Mol. Cell Biol. 19, 158–174 (2018).

    Article  PubMed  Google Scholar 

  5. Tahtinen, S. et al. Nature Immunol. 23, 532–542 (2022).

    Article  PubMed  Google Scholar 

  6. Baiersdörfer, M. et al. Mol. Ther. Nucleic Acids 15, 26–35 (2019).

    Article  Google Scholar 

  7. Karikó, K. et al. Mol. Ther. 16, 1833–1840 (2008).

    Article  PubMed  Google Scholar 

  8. Kremsner, P. G. et al. Wien. Klin. Wochenschr. 133, 931–941 (2021).

    Article  PubMed  Google Scholar 

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Competing Interests

The author declares no competing interests.


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