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  • RESEARCH BRIEFINGS

Uncovering a role for B cells in antitumour immunity

The function of immune cells called B cells in cancer has been controversial. Single-cell profiling has identified a previously undescribed subset of B cells that express a protein called TIM-1 and that multiply in response to melanoma tumour growth. Deletion of the gene that encodes TIM-1 in these cells unleashed an antitumour immune response.

This is a summary of: Bod, L. et al. B-cell-specific checkpoint molecules that regulate anti-tumour immunity. Nature https://doi.org/10.1038/s41586-023-06231-0 (2023).

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doi: https://doi.org/10.1038/d41586-023-01678-7

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