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How one man’s rare Alzheimer’s mutation delayed the onset of disease

Genetic resilience found in a person predisposed to early-onset dementia could potentially lead to new treatments.
  1. Sara Reardon
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Researchers have identified a man with a rare genetic mutation that protected him from developing dementia at an early age. The finding, published on 15 May in Nature Medicine1, could help researchers to better understand the causes of Alzheimer’s disease and potentially lead to new treatments.

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Nature 617, 660-661 (2023)

doi: https://doi.org/10.1038/d41586-023-01610-z

References

  1. Lopera, F. et al. Nature Med. https://doi.org/10.1038/s41591-023-02318-3 (2023).

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  2. Arboleda-Velasquez, J. F. et al. Nature Med. 25, 1680–1683 (2019).

    Article  PubMed  Google Scholar 

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