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A clue to the catalytic activation of splicing

The processing of messenger RNA during splicing requires the activity of a complex of RNAs and proteins termed the spliceosome. Structural data shed light on previously mysterious aspects of splicing in humans.
  1. Soo-Chen Cheng

    1. Soo-Chen Cheng is at the Institute of Molecular Biology, Academia Sinica, Taipei City 115, Taiwan.

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Most genes in eukaryotic organisms (those such as plants, animals and fungi, with cells that have a nucleus) are interrupted by non-coding sequences called introns, which need to be removed from the corresponding RNA molecule by a process called splicing. Writing in Nature, Schmitzova et al.1 provide insights into an important step needed for splicing to occur.

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Nature 617, 680-681 (2023)

doi: https://doi.org/10.1038/d41586-023-01528-6

References

  1. Schmitzova, J., Cretu, C., Dienemann, C., Urlaub, H. & Pena, V. Nature 617, 842–850 (2023).

    Article  Google Scholar 

  2. Wilkinson, M. E., Charenton, C. & Nagai, K. Annu. Rev. Biochem. 89, 359–388 (2020).

    Article  PubMed  Google Scholar 

  3. Liu, Y.-C. & Cheng, S.-C. J. Biomed. Sci. 22, 54 (2015).

    Article  PubMed  Google Scholar 

  4. De, I. et al. Nature Struct. Mol. Biol. 22, 138–144 (2015).

    Article  PubMed  Google Scholar 

  5. Yan, C., Wan, R., Bai, R. & Shi, Y. Science 353, 904–911 (2016).

    Article  PubMed  Google Scholar 

  6. Liu, H.-L. & Cheng, S.-C. Mol. Cell. Biol. 32, 5056–5066 (2012).

    Article  PubMed  Google Scholar 

  7. Schwer, B. Mol. Cell 30, 743–754 (2008).

    Article  PubMed  Google Scholar 

  8. Semlow, D. R., Blanco, M. R., Walter, N. G. & Staley, J. P. Cell 164, 985–998 (2016).

    Article  PubMed  Google Scholar 

  9. Bai, R. et al. Science 371, eabe8863 (2021).

    Article  PubMed  Google Scholar 

  10. Chung, C.-S. et al. Nucleic Acids Res. 47, 899–910 (2019).

    Article  PubMed  Google Scholar 

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Competing Interests

The author declares no competing interests.

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