Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • RESEARCH BRIEFINGS

New protein–protein interactions designed by a computer

Creating protein interactions through computational design is a key challenge in the fields of both basic and translational biology. An approach that uses the machine-learned fingerprints of protein-surface features was used to produce synthetic proteins that engage immunotherapeutic or viral targets with binding affinities comparable to those of naturally occurring proteins.

This is a summary of: Gainza, P. et al. De novo design of protein interactions with learned surface fingerprints. Nature https://doi.org/10.1038/s41586-023-05993-x (2023).

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

doi: https://doi.org/10.1038/d41586-023-01324-2

‘Expert opinion’ and the figure are published under a CC BY 4.0 licence.

References

  1. Marchand, A., Van Hall-Beauvais, A. K. & Correia, B. E. Curr. Opin. Struct. Biol. 74, 102370 (2022).

    Article  PubMed  Google Scholar 

  2. Gainza, P. et al. Nature Methods 17, 184–192 (2020).

    Article  PubMed  Google Scholar 

  3. Giordano-Attianese, G. et al. Nature Biotechnol. 38, 426–432 (2020).

    Article  PubMed  Google Scholar 

  4. Watson, J. L. et al. Preprint at bioRxiv https://doi.org/10.1101/2022.12.09.519842 (2022).

  5. Wang, J. et al. Science 377, 387–394 (2022).

    Article  PubMed  Google Scholar 

Download references

Subjects

Latest on:

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Advanced search

Quick links