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Yo-yoing stem cells defy dogma to maintain hair colour

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Nature 616, 666-667 (2023)



  1. Sun, Q. et al. Nature 616, 774–782 (2023).

    Article  Google Scholar 

  2. Blanpain, C., Horsley, V. & Fuchs, E. Cell 128, 445–458 (2007).

    Article  PubMed  Google Scholar 

  3. Greco, V. et al. Cell Stem Cell 4, 155–169 (2009).

    Article  PubMed  Google Scholar 

  4. Azkanaz, M. et al. Nature 607, 548–554 (2022).

    Article  PubMed  Google Scholar 

  5. Zhang, C. et al. Nature Aging 1, 889–903 (2021).

    Article  Google Scholar 

  6. Ito, M. et al. Nature Med. 11, 1351–1354 (2005).

    Article  PubMed  Google Scholar 

  7. Overturf, K. et al. Am. J. Pathol. 151, 1273–1280 (1997).

    PubMed  Google Scholar 

  8. Ziv, O., Glaser, B. & Dor, Y. Dev. Cell 26, 3–7 (2013).

    Article  PubMed  Google Scholar 

  9. Puri, S., Folias, A. E. & Hebrok, M. Cell Stem Cell 16, 18–31 (2020).

    Article  Google Scholar 

  10. Murata, K. et al. Cell Stem Cell 26, 377–390 (2020).

    Article  PubMed  Google Scholar 

  11. Waddington, C. H. The Strategy of Genes 1st edn (Geo Allen & Unwin, 1957).

    Google Scholar 

  12. Watanabe, A., Yamada, Y. & Yamanaka, S. Phil. Trans. R. Soc. Lond. B 368, 20120292 (2013).

    Article  Google Scholar 

  13. Takeda, K. et al. J. Biol. Chem. 275, 14013–14016 (2000).

    Article  PubMed  Google Scholar 

  14. Moon, H. et al. Cell Stem Cell 21, 665–678 (2017).

    Article  PubMed  Google Scholar 

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Competing Interests

W.E.L. is president of and holds equity in Pelage Pharmaceuticals, a company devoted to developing therapies for alopecia (hair loss).


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