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MicroRNA uses a gym to get fit for cuts by Dicer enzyme

The enzyme Dicer cleaves a type of RNA called a pre-microRNA to make the mature functional RNA. Structural evidence now sheds light on the catalytic mechanism involved and the role of a newly found RNA sequence termed GYM.
  1. Gunter Meister

    1. Gunter Meister is at the Regensburg Center for Biochemistry, University of Regensburg, 93053 Regensburg, Germany.

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Gene expression can be silenced through targeted pathways that depend on small RNAs. Writing in Nature, Lee et al.1,2 provide insights into a key step in the maturation of such RNAs that is mediated by the enzyme Dicer.

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Nature 615, 218-219 (2023)

doi: https://doi.org/10.1038/d41586-023-00478-3

References

  1. Lee, Y.-Y., Kim, H. & Kim, V. N. Nature 615, 323–330 (2023).

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  2. Lee, Y.-Y., Lee, H., Kim, H., Kim, V. N. & Roh, S.-H. Nature 615, 331–338 (2023).

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  3. Treiber, T., Treiber, N. & Meister, G. Nature Rev. Mol. Cell Biol. 20, 5–20 (2019).

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Competing Interests

The author declares no competing interests.

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