Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • RESEARCH BRIEFINGS

Genome doubling perturbs DNA packing and promotes cancer development

Cells in which the whole genome has been doubled do not upscale protein synthesis to cope with the increase in DNA. Instead, a shortage of proteins that regulate the packing of DNA in the nucleus leads to poor segregation of DNA structures, which eventually contributes to the development of cancer.

This is a summary of: Lambuta R. A. et al. Whole-genome doubling drives oncogenic loss of chromatin segregation. Nature https://doi.org/10.1038/s41586-023-05794-2 (2023).

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

doi: https://doi.org/10.1038/d41586-023-00426-1

‘Expert opinion’ and the figure are published under a CC BY 4.0 licence.

References

  1. Bielski, C. M. et al. Nature Genet. 50, 1189–1195 (2018).

    Article  PubMed  Google Scholar 

  2. Bonev, B. & Cavalli, G. Nature Rev. Genet. 17, 661–678 (2016).

    Article  PubMed  Google Scholar 

  3. Dewhurst, S. M. et al. Cancer Discov. 4, 175–185 (2014).

    Article  PubMed  Google Scholar 

  4. Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).

    Article  PubMed  Google Scholar 

Download references

Subjects

Latest on:

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Advanced search

Quick links