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  • RESEARCH HIGHLIGHT

Genome editor tackles disease that can cause sudden death

Scientists repair a mutation that causes heart-muscle abnormalities and can kill without warning.
A composite of three images of different mouse hearts

A conventional mouse’s heart (left) looks similar to the heart (middle) of a mouse engineered to have one copy of a disease-causing gene; both contrast with the heart (right) of a mouse with two copies of the gene. Credit: A. C. Chai et al./Nat. Med.

Genome editing can correct a genetic mutation that can cause a sudden and early death from heart abnormalities, according to a study in mice and in human cells grown in the laboratory1.

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Nature 614, 596 (2023)

doi: https://doi.org/10.1038/d41586-023-00410-9

References

  1. Chai, A. C. et al. Nature Med. https://doi.org/10.1038/s41591-022-02176-5 (2023).

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