Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


How a pioneering diabetes drug offers hope for preventing autoimmune disorders

Mikayla Olsten poses for a portrait while sitting on her bed in her dorm room

Student Mikayla Olsten received the antibody therapy teplizumab in 2016, which has kept her from developing symptoms of type 1 diabetes. Credit: Natalie Behring for Nature

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Nature 614, 404-406 (2023)



  1. Sims, E. K. et al. Sci. Transl. Med. 13, eabc8980 (2021).

    Article  PubMed  Google Scholar 

  2. Herold, K. C. et al. N. Engl. J. Med. 381, 603–613 (2019).

    Article  PubMed  Google Scholar 

  3. Kung, P. C., Goldstein, G., Reinherz, E. L. & Schlossman, S. F. Science 206, 347–379 (1979).

    Article  Google Scholar 

  4. Herold, K. C. et al. Clin. Immunol. 132, 166–173 (2009).

    Article  PubMed  Google Scholar 

  5. Sherry, N. et al. Lancet 378, 487–497 (2011).

    Article  PubMed  Google Scholar 

  6. Aronson, R. et al. Diab. Care 37, 2746–2754 (2014).

    Article  PubMed  Google Scholar 

  7. Long, A. S. et al. Sci. Immunol. 1, eaai7793 (2016).

    Article  PubMed  Google Scholar 

  8. Pagni, P. P. et al. Diabetes 71, 157–169 (2022).

    Article  Google Scholar 

  9. Bonifacio, E. et al. JAMA 313, 1541–1549 (2015).

    Article  PubMed  Google Scholar 

  10. Rech, J. et al. Ann. Rheum. Dis. 81 (Suppl. 1), 526-527 (2022).

    Article  Google Scholar 

  11. Okuda, D. T. et al. Ann. Neurol. (2022).

    Article  Google Scholar 

  12. Ziegler, A.-G. et al. JAMA 323, 339–351 (2020).

    Article  PubMed  Google Scholar 

Download references


Latest on:

Nature Careers


  • Postdoctoral fellow

    Investigations on Alzheimer's disease pathology and the search for novel therapeutic strategies.

    Montréal, Quebec (CA)

    Prof. A. Claudio Cuello

  • Postdoctoral positions at University of Pennsylvania

    Postdoctoral positions funded by NIH are for study of meiosis and spermatogonial stem cells using mouse models. Generous stipend and benefits.

    Philadelphia, Pennsylvania (US)

    University of Pennsylvania - Department of Biomedical Sciences

  • Associate or Senior Editor, Nature Communications (Materials Science)

    Associate or Senior Editor (Materials Science) Organization: Nature Communications Location(s): New York, Jersey City, Philadelphia, Beijing, Hong ...

    New York (US)

    Springer Nature Ltd

  • Associate or Senior Editor, Nature Medicine

    Associate or Senior, Nature Medicine: Infectious Diseases New York, Shanghai or Beijing - Hybrid Working Application Deadline: August 1, 2024   Nat...

    New York City, New York (US)

    Springer Nature Ltd

  • Post-doctoral Fellow

    Funded investigator has an immediate opening for a post-doctoral fellow to develop therapies for genetic diseases.

    Johns Hopkins School of Medicine, East Baltimore Campus

    Johns Hopkins University Department of Medicine

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing


Quick links