The β-selection step shapes T-cell identity

Rothenberg, Ellen V.

doi:10.1038/d41586-023-00025-0

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16 January 2023

The β-selection step shapes T-cell identity

T cells of the immune system develop through a lineage-commitment step followed by two checkpoints. The finding that the first checkpoint is needed to complete commitment offers a fresh perspective on T-cell development.

Ellen V. Rothenberg⁰

Ellen V. Rothenberg
1. Ellen V. Rothenberg is in the Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
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Cancer and infected cells are targeted by T cells of the immune system. Writing in Nature, Duke-Cohan et al.¹ present insights into the early events that drive the formation of T cells.

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Nature 613, 440-442 (2023)

doi: https://doi.org/10.1038/d41586-023-00025-0

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