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A transient protein megacomplex that controls degradation of cell components

Whether to self-degrade is a crucial cellular decision. When nutrients are abundant, degradation of cell components is reduced through inactivation of a protein called TFEB by the enzyme complex mTORC1. The structure of a megacomplex consisting of 36 polypeptide chains, which presents TFEB to mTORC1, has been resolved.

This is a summary of: Cui, Z. et al. Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex. Nature https://doi.org/10.1038/s41586-022-05652-7 (2023).

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doi: https://doi.org/10.1038/d41586-022-04538-y

‘Expert opinion’ and the figure are published under a CC BY 4.0 licence.

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