A spatial perspective on bacteria in tumours

Livyatan, Ilana; Straussman, Ravid

doi:10.1038/d41586-022-03669-6

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16 November 2022

A spatial perspective on bacteria in tumours

Bacteria are frequently present in human cancers. The use of state-of-the-art methods for tumour analysis that capture spatial information and single-cell molecular profiles paves the way to clarifying the roles of these microorganisms.

Ilana Livyatan
1. Ilana Livyatan is in the Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
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Ravid Straussman
1. Ravid Straussman is in the Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
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By gathering highly detailed ‘portraits’ of tumours, Galeano Niño et al.¹, writing in Nature, identify the locations of tumour-associated bacteria. The findings reveal how these bacteria interact with various cell types in the tumours.

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Nature 611, 674-675 (2022)

doi: https://doi.org/10.1038/d41586-022-03669-6

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Competing Interests

R.S. is a paid consultant and has stock interest in Micronoma, CuResponse, Biomica and Baccine. He is a paid consultant to Merk - Sigma-Aldrich, Israel, and for City of hope, USA. He is a member of the scientific advisory board of Micronoma; received a grant from Merck EMD Serono; and is a co-inventor on multiple patents related to the use of intratumour microbes as diagnostic or prognostic markers or for therapeutic opportunities.