35 years of channelling potassium ions

Nimigean, Crina M.

doi:10.1038/d41586-022-02163-3

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15 August 2022

35 years of channelling potassium ions

In 1987, two independent groups cloned a gene that encoded the potassium-ion-channel protein Shaker, enabling functional and structural studies that have transformed ion-channel research.

Crina M. Nimigean⁰

Crina M. Nimigean
1. Crina M. Nimigean is in the Department of Anesthesiology and in the Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York 10021, USA.
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Nerve impulses travel through cells as trains of electrical signals called action potentials, which arise from fast changes in voltage when ions move across the neuronal membrane. The membrane-spanning ion-channel proteins that mediate this process have fascinated scientists for more than half a century, since their existence was first proposed. The channels not only select for their preferred ion type — sodium (Na⁺), calcium (Ca²⁺) or potassium (K⁺) — but also sense changes in transmembrane voltage and respond by regulating the flow of ions through their pores. In 1987, a group headed by Mark Tanouye¹, and another led by partners Lily and Yuh-Nung Jan²^,³, took a key step towards understanding voltage-gated ion channels, identifying the first gene that encoded a K⁺ channel. Their work opened the door to a tsunami of investigations, eventually leading to the determination of high-resolution structures for a wealth of K⁺ channels.

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Nature 608, 670-672 (2022)

doi: https://doi.org/10.1038/d41586-022-02163-3

References

Kamb, A., Iverson, L. E. & Tanouye, M. A. Cell 50, 405–413 (1987).
Article PubMed Google Scholar
Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N. & Jan, L. Y. Science 237, 749–753 (1987).
Article PubMed Google Scholar
Tempel, B. L., Papazian, D. M., Schwarz, T. L., Jan, Y. N. & Jan, L. Y. Science 237, 770–775 (1987).
Article PubMed Google Scholar
Jan, Y. N., Jan, L. Y. & Dennis, M. J. Proc. R. Soc. Lond. B 198, 87–108 (1977).
Article PubMed Google Scholar
Noda, M. et al. Nature 312, 121–127 (1984).
Article PubMed Google Scholar
Timpe, L. C. et al. Nature 331, 143–145 (1988).
Article PubMed Google Scholar
Jan, L. Y. & Jan, Y. N. Annu. Rev. Physiol. 54, 537–555 (1992).
Article PubMed Google Scholar
Miller, C. Science 252, 1092–1096 (1991).
Article PubMed Google Scholar
Heginbotham, L., Abramson, T. & MacKinnon, R. Science 258, 1152–1155 (1992).
Article PubMed Google Scholar
Hoshi, T., Zagotta, W. N. & Aldrich, R. W. Science 250, 533–538 (1990).
Article PubMed Google Scholar
Hoshi, T., Zagotta, W. N. & Aldrich, R. W. Neuron 7, 547–556 (1991).
Article PubMed Google Scholar
Bezanilla, F. Physiol. Rev. 80, 555–592 (2000).
Article PubMed Google Scholar
Doyle, D. et al. Science 280, 69–77 (1998).
Article PubMed Google Scholar
Zhou, Y., Morais-Cabral, J. H., Kaufman, A. & MacKinnon, R. Nature 414, 43–48 (2001).
Article PubMed Google Scholar
Cordero-Morales, J. F. et al. Nature Struct. Mol. Biol. 13, 311–318 (2006).
Article PubMed Google Scholar
Long, S. B., Campbell, E. B. & Mackinnon, R. Science 309, 897–903 (2005).
Article PubMed Google Scholar
Fan, C. et al. Nature 580, 288–293 (2020).
Article PubMed Google Scholar
Lacroix, J. J., Campos, F. V., Frezza, L. & Bezanilla, F. Neuron 79, 651–657 (2013).
Article PubMed Google Scholar
Wulff, H., Christophersen, P., Colussi, P., Chandy, K. G. & Yarov-Yarovoy, V. Nature Rev. Drug Discov. 18, 339–357 (2019).
Article PubMed Google Scholar
Jiang, Y. et al. Nature 417, 523–526 (2002).
Article PubMed Google Scholar

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[1] Kamb, A., Iverson, L. E. & Tanouye, M. A. Cell 50, 405–413 (1987).
Article PubMed Google Scholar

[2] Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N. & Jan, L. Y. Science 237, 749–753 (1987).
Article PubMed Google Scholar

[3] Tempel, B. L., Papazian, D. M., Schwarz, T. L., Jan, Y. N. & Jan, L. Y. Science 237, 770–775 (1987).
Article PubMed Google Scholar

[4] Jan, Y. N., Jan, L. Y. & Dennis, M. J. Proc. R. Soc. Lond. B 198, 87–108 (1977).
Article PubMed Google Scholar

[5] Noda, M. et al. Nature 312, 121–127 (1984).
Article PubMed Google Scholar

[6] Timpe, L. C. et al. Nature 331, 143–145 (1988).
Article PubMed Google Scholar

[7] Jan, L. Y. & Jan, Y. N. Annu. Rev. Physiol. 54, 537–555 (1992).
Article PubMed Google Scholar

[8] Miller, C. Science 252, 1092–1096 (1991).
Article PubMed Google Scholar

[9] Heginbotham, L., Abramson, T. & MacKinnon, R. Science 258, 1152–1155 (1992).
Article PubMed Google Scholar

[10] Hoshi, T., Zagotta, W. N. & Aldrich, R. W. Science 250, 533–538 (1990).
Article PubMed Google Scholar

[11] Hoshi, T., Zagotta, W. N. & Aldrich, R. W. Neuron 7, 547–556 (1991).
Article PubMed Google Scholar

[12] Bezanilla, F. Physiol. Rev. 80, 555–592 (2000).
Article PubMed Google Scholar

[13] Doyle, D. et al. Science 280, 69–77 (1998).
Article PubMed Google Scholar

[14] Zhou, Y., Morais-Cabral, J. H., Kaufman, A. & MacKinnon, R. Nature 414, 43–48 (2001).
Article PubMed Google Scholar

[15] Cordero-Morales, J. F. et al. Nature Struct. Mol. Biol. 13, 311–318 (2006).
Article PubMed Google Scholar

[16] Long, S. B., Campbell, E. B. & Mackinnon, R. Science 309, 897–903 (2005).
Article PubMed Google Scholar

[17] Fan, C. et al. Nature 580, 288–293 (2020).
Article PubMed Google Scholar

[18] Lacroix, J. J., Campos, F. V., Frezza, L. & Bezanilla, F. Neuron 79, 651–657 (2013).
Article PubMed Google Scholar

[19] Wulff, H., Christophersen, P., Colussi, P., Chandy, K. G. & Yarov-Yarovoy, V. Nature Rev. Drug Discov. 18, 339–357 (2019).
Article PubMed Google Scholar

[20] Jiang, Y. et al. Nature 417, 523–526 (2002).
Article PubMed Google Scholar

35 years of channelling potassium ions

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