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Persister cells that survive chemotherapy are pinpointed

A close look at the cells that drive cancer growth after chemotherapy, and thereby contribute to fatal tumour progression, provides new insights into the identity of the cells that manage to survive treatment.
  1. Sumaiyah K. Rehman

    1. Sumaiyah K. Rehman is at the Princess Margaret Cancer Center, University Health Network, Toronto, Ontario M5G 1L7, Canada.

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  2. Catherine A. O’Brien

    1. Catherine A. O’Brien is in the Department of Surgery, University Health Network, Toronto, Ontario M5G 1L7, Canada, at the Princess Margaret Cancer Center, and in the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto.

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Chemotherapy does not always succeed in tackling a tumour. Understanding how cancer growth resumes after chemotherapy will be key to finding new treatments that might lead to sustainable cures. Writing in Nature, Ohta et al.1 fill in some missing details about the cells that drive such tumour relapses.

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Nature 608, 675-676 (2022)

doi: https://doi.org/10.1038/d41586-022-01866-x

References

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Competing Interests

The authors declare no competing interests.

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