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Olfactory receptors are not unique to the nose

The hundreds of receptors that give us our sense of smell have been found to have important roles in other parts of the body, and the prospect of targeting them with drugs is growing.
  1. Liam Drew

    1. Liam Drew is a freelance writer in Kent, UK.

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People are estimated to be able to discriminate between anywhere from 10,000 to more than one trillion different smells. In the early 1990s, our understanding of how that can be possible took a big step forward.

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Nature 606, S14-S17 (2022)

doi: https://doi.org/10.1038/d41586-022-01631-0

This article is part of Nature Outlook: Smell, an editorially independent supplement produced with the financial support of third parties. About this content.

References

  1. Buck, L. & Axel, R. Cell 65, 175–187 (1991).

    Article  PubMed  Google Scholar 

  2. Orecchioni, M. et al. Science 375, 214–221 (2022).

    Article  PubMed  Google Scholar 

  3. Parmentier, M. et al. Nature 355, 453–455 (1992).

    Article  PubMed  Google Scholar 

  4. Zhang, X. et al. Proc. Natl Acad. Sci. USA 101, 14168–14173 (2004).

    Article  PubMed  Google Scholar 

  5. Spehr, M. et al. Science 299, 2054–2058 (2003).

    Article  PubMed  Google Scholar 

  6. Neuhaus, E. M. et al. J. Biol. Chem. 284, 16218–16225 (2009).

    Article  PubMed  Google Scholar 

  7. Busse, D. et al. J. Invest. Dermatol. 134, 2823–2832 (2014).

    Article  PubMed  Google Scholar 

  8. Jimenez, F. et al. J. Cosmet. Dermatol. 20, 784–791 (2021).

    Article  PubMed  Google Scholar 

  9. Pluznick, J. L. et al. Proc. Natl Acad. Sci. USA 106, 2059–2064 (2009).

    Article  PubMed  Google Scholar 

  10. Pluznick, J. L. et al. Proc. Natl Acad. Sci. USA 110, 4410–4415 (2013).

    Article  PubMed  Google Scholar 

  11. Pluznick, J. Gut Microbes 5, 202–207 (2014).

    Article  PubMed  Google Scholar 

  12. Shepard, B. D. et al. Sci. Rep. 6, 35215 (2016).

    Article  PubMed  Google Scholar 

  13. Li, E. et al. Cell Metab. 30, 319–328 (2019).

    Article  PubMed  Google Scholar 

  14. Cheng, J. et al. Cell Metab. 34, 240–255 (2022).

    Article  PubMed  Google Scholar 

Download references

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