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  • OUTLOOK

The science of smell steps into the spotlight

Abstract illustration showing a woman surrounded by colourful swirls of different smells.

Image: Sam Falconer

For millions of people, one of the defining symptoms of COVID-19 has been the loss of their sense of smell. Many are now experiencing the world with a diminished or otherwise altered capacity to detect odours. Gone is their ability to enjoy the aroma of food or nature. The sheer number of people affected means that olfaction, for so long overlooked among our suite of senses, is finally stepping into the scientific spotlight.

Much of that newfound attention is medically oriented. Researchers have worked rapidly to understand how COVID-19 brings about the loss of a person’s sense of smell — a condition known as anosmia — and why the effect varies between individuals and between variants of the coronavirus SARS-CoV-2. This has led to renewed interest in treating anosmia, which will benefit not only those who have the condition as a result of COVID-19, but also the 5–12% of the general population who already have an olfactory condition. Efforts to improve established olfactory-training techniques could bear fruit quickly, whereas attempts to develop electronic implants to restore a person’s sense of smell have much further to go. The potential use of dogs to sniff out human diseases, such as infections or cancer, is also gathering steam.

Away from medicine, researchers are gaining insight into the inner workings of human olfaction. The neurobiology that underpins the close link between smell and memory, which makes certain odours so immediately evocative of another place and time, is yielding its secrets. The influence that smells have on human behaviour, affecting our emotional states and choice of partner, is also becoming clear. And even the seemingly strange discovery of olfactory receptors in tissues and organs around the human body is beginning to be explained. Taking all of these changes together, it seems as if the world has woken up to the special importance of smell.

We are pleased to acknowledge the financial support of Firmenich in producing this Outlook. As always, Nature retains sole responsibility for all editorial content.

Nature 606, S1 (2022)

doi: https://doi.org/10.1038/d41586-022-01625-y

This article is part of Nature Outlook: Smell, an editorially independent supplement produced with the financial support of third parties. About this content.

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