Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • NEWS FEATURE

Guardians of the brain: how a special immune system protects our grey matter

Micrograph showing close up of a mouse brain at the confluence of dural sinuses with meningeal lymphatic vessels and immune cell

The brain’s immune system includes a network of transport vessels (blue) and its own immune cells made in the bone marrow (green). Credit: Siling Du, Kipnis lab, Washington University in St. Louis

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Nature 606, 22-24 (2022)

doi: https://doi.org/10.1038/d41586-022-01502-8

References

  1. Shirai, Y. Jap. Med. World 1, 14–15 (1921).

    Google Scholar 

  2. Mascagni, P. Vasorum Lymphaticorum Corporis Humani Historia et Ichnographia (Pazzini Carli, 1787).

    Google Scholar 

  3. Moalem, G. et al. Nature Med. 5, 49–55 (1999).

    Article  PubMed  Google Scholar 

  4. Beers, D. R., Henkel, J. S., Zhao, W., Wang, J. & Appel, S. H. Proc. Natl Acad. Sci. USA 105, 15558–15563 (2008).

    Article  PubMed  Google Scholar 

  5. Gate, D. et al. Nature 577, 399–404 (2020).

    Article  PubMed  Google Scholar 

  6. Baruch, K. et al. Nature Med. 22, 135–137 (2016).

    Article  PubMed  Google Scholar 

  7. Cugurra, A. et al. Science 373, eabf7844 (2021).

    Article  PubMed  Google Scholar 

  8. Mazzitelli, J. A. et al. Nature Neurosci. 25, 555–560 (2022).

    Article  PubMed  Google Scholar 

  9. Louveau, A. et al. Nature 523, 337–341 (2015).

    Article  PubMed  Google Scholar 

  10. Filiano, A. J. et al. Nature 535, 425–429 (2016).

    Article  PubMed  Google Scholar 

  11. Pasciuto, E. et al. Cell 182, 625–640 (2020).

    Article  PubMed  Google Scholar 

  12. Krueger, J. M., Walter, J., Dinarello, C. A., Wolff, S. M. & Chedid, L. Am. J. Physiol. 246, R994–R999 (1984).

    Article  PubMed  Google Scholar 

  13. Salvador, A. F., de Lima, K. A. & Kipnis, J. Nature Rev. Immunol. 21, 526–541 (2021).

    Article  PubMed  Google Scholar 

  14. Choi, G. B. et al. Science 351, 933–939 (2016).

    Article  PubMed  Google Scholar 

  15. Ader, R. & Cohen, N. Psychosom. Med. 37, 333–340 (1975).

    Article  PubMed  Google Scholar 

  16. Ben-Shaanan, T. L. et al. Nature Commun. 9, 2723 (2018).

    Article  PubMed  Google Scholar 

  17. Koren, T. et al. Cell 184, 5902–5915 (2021).

    Article  PubMed  Google Scholar 

Download references

Subjects

Latest on:

Nature Careers

Jobs

  • Postdoctoral Fellow

    The Dubal Laboratory of Neuroscience and Aging at the University of California, San Francisco (UCSF) seeks postdoctoral fellows to investigate the ...

    San Francisco, California

    University of California, San Francsico

  • Postdoctoral Associate

    Houston, Texas (US)

    Baylor College of Medicine (BCM)

  • Postdoctoral Research Fellow

    Description Applications are invited for a postdoctoral fellow position at the Lunenfeld-Tanenbaum Research Institute, Sinai Health, to participate...

    Toronto (City), Ontario (CA)

    Sinai Health

  • Postdoctoral Research Associate - Surgery

    Memphis, Tennessee

    St. Jude Children's Research Hospital (St. Jude)

  • Open Rank Faculty Position in Biochemistry and Molecular Genetics

    The Department of Biochemistry & Molecular Genetics (www.virginia.edu/bmg) and the University of Virginia Cancer Center

    Charlottesville, Virginia

    Biochemistry & Molecular Genetics

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Quick links