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  • RESEARCH BRIEFINGS

Tumour driver mutations compromise between cancer growth and immune responses

Various theories have tried to explain the frequency and consistency of ‘hotspot’ mutations in many tumour-driving genes across different cancers. A model of the fitness benefit of these mutations shows that fundamental trade-offs occur between a tumour’s growth and its visibility to the immune system, with potential therapeutic implications.

This is a summary of: Hoyos, D. et al. Fundamental immune–oncogenicity trade-offs define driver mutation fitness. Nature https://doi.org/10.1038/s41586-022-04696-z (2022).

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doi: https://doi.org/10.1038/d41586-022-01138-8

Figure 1 is published under a CC BY 4.0 licence.

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