Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correction 10 May 2022

Base edit your way to better crops

Caixia Gao and a member of her research team inspect CRISPR-modified tomato crops in a greenhouse

Caixia Gao and a member of her team inspect CRISPR-modified tomato plants in a greenhouse at their growing facility in Beijing. Credit: Stefen Chow

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Nature 604, 790-792 (2022)


Updates & Corrections

  • Correction 10 May 2022: An earlier version of this Technology feature article erroneously implied that Pairwise’s leafy green vegetable was being base-edited to improve the nutritional content. In fact, the firm used standard CRISPR and targeted flavour. Also, the stoneless cherry is not yet in field testing.


  1. Xing, S. et al. Genome Biol. 21, 230 (2020).

    Article  PubMed  Google Scholar 

  2. Komor, A. et al. Nature 533, 420–424 (2016).

    Article  PubMed  Google Scholar 

  3. Gaudelli, N. et al. Nature 551, 464–471 (2017).

    Article  PubMed  Google Scholar 

  4. Bastet, A. et al. Plant Biotechnol. J. 17, 1736–1750 (2019).

    Article  PubMed  Google Scholar 

  5. Zhang, R. et al. Nature Plants 5, 480–485 (2019).

    Article  PubMed  Google Scholar 

  6. Li, C. et al. Nature Biotechnol. 38, 875–882 (2020).

    Article  PubMed  Google Scholar 

  7. Sretenovic, S. et al. Front. Genome Ed. 3, 756766 (2021).

    Article  PubMed  Google Scholar 

  8. Anzalone, A. V. et al. Nature 576, 149–157 (2019).

    Article  PubMed  Google Scholar 

  9. Zong, Y. et al. Nature Biotechnol. (2022).

    Article  Google Scholar 

  10. Lin, Q. et al. Nature Biotechnol. 39, 923–927 (2021).

    Article  PubMed  Google Scholar 

  11. Kong, J. et al. Front. Plant Sci. (2020).

    Article  Google Scholar 

  12. Li, T. et al. Nature Biotechnol. 36, 1160–1163 (2018).

    Article  Google Scholar 

Download references


Latest on:

Nature Careers


Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing


Quick links