Mutational clocks tick differently across species

Gorelick, Alexander N.; Naxerova, Kamila

doi:10.1038/d41586-022-00976-w

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13 April 2022

Mutational clocks tick differently across species

Throughout life, cells accrue mutations. It now emerges that longer-lived animals acquire mutations at a slower rate than do short-lived species, potentially explaining why cancer risk does not increase with lifespan.

Alexander N. Gorelick⁰ &
Kamila Naxerova¹

Alexander N. Gorelick
1. Alexander N. Gorelick is in the Department of Radiology and at the Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.
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Kamila Naxerova
1. Kamila Naxerova is in the Department of Radiology and at the Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA.
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The animal kingdom comprises amazing diversity, ranging from small, short-lived animals to large, long-lived species. How does the risk of developing cancer manifest across these different life forms, and what are the molecular underpinnings of this? Writing in Nature, Cagan et al.¹ and Vincze et al.² provide some answers.

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Nature 604, 435-436 (2022)

doi: https://doi.org/10.1038/d41586-022-00976-w

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