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  • RESEARCH BRIEFINGS

Determining the structure of fleeting protein states

Proteins adopt unstable, high-energy states that exist for fractions of a second but can have key biological roles. A new method of determining high-resolution structures of such states using a form of nuclear magnetic resonance reveals how small changes in protein shape are essential to their function.

This is a summary of: Stiller, J. B. et al. Structure determination of high-energy states in a dynamic protein ensemble. Nature https://doi.org/10.1038/s41586-022-04468-9 (2022).

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doi: https://doi.org/10.1038/d41586-022-00531-7

‘Expert opinion’ is published under a CC BY 4.0 licence.

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