Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


What the Omicron wave is revealing about human immunity

A health worker transfers a dose of Moderna's COVID-19 vaccine into a syringe at a vaccination drive in a stadium in Manila

A health worker in the Philippines prepares a dose of COVID-19 vaccine during the January surge of Omicron cases. Credit: Basilio Sepe/ZUMA Wire/Shutterstock

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Nature 602, 22-25 (2022)



  1. Andrews, N. et al. Preprint at medRxiv (2021).

  2. Tseng, H. F. et al. Preprint at medRxiv (2021).

  3. Long, Q-.X. et al. Nature Med. 26, 1200–1204 (2020).

    Article  PubMed  Google Scholar 

  4. Ibarrondo, F. J. et al. N. Engl. J. Med. 383, 1085–1087 (2020).

    Article  PubMed  Google Scholar 

  5. Cohen, K. W. et al. Cell Rep. Med. 2, 100354 (2021).

    Article  PubMed  Google Scholar 

  6. Goel, R. R. et al. Science 374, eabm0829 (2021).

    Article  Google Scholar 

  7. Swadling, L. et al. Nature 601, 110–117 (2022).

    Article  PubMed  Google Scholar 

  8. Keeton, R. et al. Preprint at medRxiv (2021).

  9. Gao, Y. et al. Nature Med. (2022).

    Article  Google Scholar 

  10. Chen, J. S. et al. Sci. Immunol. (2021).

    Article  Google Scholar 

  11. Garcia-Beltran, W. F. et al. Cell (2021).

    Article  Google Scholar 

  12. Tarke, A. et al. Cell (2022).

    Article  Google Scholar 

  13. UK Health Security Agency. SARS-CoV-2 Variants of Concern and Variants Under Investigation in England: Technical Briefing 33 (2021).

  14. Slifka, M. A. & Amanna, I. J. Front. Immunol. (2019).

    Article  Google Scholar 

  15. Stuart, A. S. V. et al. Lancet 399, 36–49 (2022).

    Article  PubMed  Google Scholar 

Download references


Latest on:

Nature Careers


  • Endowed Chair in Macular Degeneration Research

    Dallas, Texas (US)

    The University of Texas Southwestern Medical Center (UT Southwestern Medical Center)

  • Postdoctoral Fellow

    Postdoc positions on ERC projects – cellular stress responses, proteostasis and autophagy

    Frankfurt am Main, Hessen (DE)

    Goethe University (GU) Frankfurt am Main - Institute of Molecular Systems Medicine

  • ZJU 100 Young Professor

    Promising young scholars who can independently establish and develop a research direction.

    Hangzhou, Zhejiang, China

    Zhejiang University

  • Qiushi Chair Professor

    Distinguished scholars with notable achievements and extensive international influence.

    Hangzhou, Zhejiang, China

    Zhejiang University

  • Research Postdoctoral Fellow - MD

    Houston, Texas (US)

    Baylor College of Medicine (BCM)

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing


Quick links