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Three, four or more: what’s the magic number for booster shots?

COVID vaccine boosters are proving a useful tool against Omicron, but scientists say that endless boosting might not be a practical or sustainable strategy.
  1. Clare Watson

    1. Clare Watson is a freelance writer in Wollongong, Australia.

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Late last year, studies showed that third shots (boosters) of COVID vaccines were effective at providing a little extra protection from infection — particularly in the face of the Omicron variant. Some countries are now offering fourth doses, but scientists say that endless boosting might not be a viable strategy, nor is it how these vaccines were meant to be used.

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Nature 602, 17-18 (2022)

doi: https://doi.org/10.1038/d41586-022-00200-9

References

  1. Gardner, B. J. & Kilpatrick, M. Preprint at medRxiv https://doi.org/10.1101/2021.12.10.21267594 (2021).

  2. Belik, M. et al. Preprint at Research Square https://doi.org/10.21203/rs.3.rs-1199296/v1 (2022).

  3. Levine-Tiefenbrun, M. et al. Preprint at medRxiv https://doi.org/10.1101/2021.12.27.21268424 (2021).

  4. Xia, H. et al. Preprint at bioRxiv https://doi.org/10.1101/2022.01.21.476344 (2022).

  5. Goel, R. G. et al. Science https://doi.org/10.1126/science.abm0829 (2021).

    Article  Google Scholar 

  6. Naranbhai, V. et al. Preprint at medRxiv https://doi.org/10.1101/2022.01.04.21268586 (2022).

  7. Barda, N. et al. Lancet https://doi.org/10.1016/S0140-6736(21)02249-2 (2021).

    Article  PubMed  Google Scholar 

  8. Andrews, N. et al. Nature Med. https://doi.org/10.1038/s41591-022-01699-1 (2022).

    Article  Google Scholar 

  9. Arbel, R. et al. N. Engl. J. Med. https://doi.org/10.1056/NEJMoa2115624 (2021).

    Article  PubMed  Google Scholar 

  10. Garcia-Beltran, W. F. et al. Cell https://doi.org/10.1016/j.cell.2021.12.033 (2021).

    Article  Google Scholar 

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