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  • OUTLOOK

Ageing

Cartoon of a small figure tries to push back the hands of a clock superimposed on the head of a larger human

Illustration: Sam Falconer

When Oscar Wilde left prison in 1897, shocked observers saw how a two-year sentence with hard labour for gross indecency had prematurely aged the Irish playwright. Shunned by London society and ostracized by his family, he died penniless in Paris three years later, aged 46. Had the scientific field of human ageing been as active then as it is now, the apparent change in Wilde’s biological age might have been of interest to researchers. Indeed, the loneliness, stress and exposure to infectious disease that he endured during his incarceration are particularly relevant today as we consider the impact of a global pandemic.

One of Wilde’s best-known literary creations is Dorian Gray, whose Faustian pact ensures that a portrait in the attic reflects the ravages of time while he remains young. Can science deliver what the devil did for Gray and stave off the effects of ageing? Some biotechnology start-ups are looking to boost autophagy, in which cells shed damaged constituents, to combat age-related disease. But when it comes to shifting someone’s biological age, researchers are divided on the extent to which epigenetic clocks — machine-learning algorithms that rely on the methylation of DNA — can effectively measure the efficacy of anti-ageing interventions. There are similar divisions around whether or not we have reached the limit of the human lifespan.

What is not disputed is the huge cost of supporting an ageing population. Advanced economies look to Japan for inspiration, where one in three people will be over 65 by 2036. Robots are touted as cost-effective solutions for homes and hospitals, but not everyone is convinced.

As ageing societies grow in size, so does their diversity. The United Kingdom partly decriminalized homosexuality, Wilde’s ‘crime’, in 1967. The LGBTQ+ people who came of age then face particular problems as they grow older and enter heteronormative care-home settings.

In this United Nations Decade of Healthy Ageing (2021–30), we are pleased to acknowledge the financial support of Tokushima University, Japan, in producing this Outlook. As always, Nature retains sole responsibility for all editorial content.

Nature 601, S1 (2022)

doi: https://doi.org/10.1038/d41586-022-00069-8

This article is part of Nature Outlook: Ageing, an editorially independent supplement produced with the financial support of third parties. About this content.

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