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A subset of immune-system T cells branded as seeds for type 1 diabetes

The identification of a specific subpopulation of immune-system T cells that drives type 1 diabetes provides insight into the development of autoimmune disease, and could point the way to new therapies.
  1. Stephen J. Turner

    1. Stephen J. Turner is in the Department of Microbiology, Biomedical Discovery Institute, Monash University, Victoria 3800, Australia.

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  2. Nicole L. La Gruta

    1. Nicole L. La Gruta is in the Department of Biochemistry and Molecular Biology, Immunity Theme, Biomedical Discovery Institute, Monash University, Victoria 3800, Australia.

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A characteristic of many autoimmune diseases, including type 1 diabetes, is an immune response that persists and does not resolve. Writing in Nature, Gearty et al.1 pinpoint a specific group of T cells in the immune system that sustain this autoimmune response. The finding has implications for treatments that seek to modulate immune responses.

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Nature 602, 35-36 (2022)

doi: https://doi.org/10.1038/d41586-021-03800-z

References

  1. Gearty, S. V. et al. Nature 602, 156–161 (2022).

    Article  Google Scholar 

  2. Khan, O. et al. Nature 571, 211–218 (2019).

    Article  PubMed  Google Scholar 

  3. McLane, L. M., Abdel-Hakeem, M. S. & Wherry, E. J. Annu. Rev. Immunol. 37, 457–495 (2019).

    Article  PubMed  Google Scholar 

  4. Yao, C. et al. Nature Immunol. 20, 890–901 (2019).

    Article  PubMed  Google Scholar 

  5. Bluestone, J. A., Herold, K. & Eisenbarth, G. Nature 464, 1293–1300 (2010).

    Article  PubMed  Google Scholar 

  6. Lin, W.-H. W. et al. Cell Rep. 17, 1773–1782 (2016).

    Article  PubMed  Google Scholar 

  7. Zhou, X. et al. Immunity 33, 229–240 (2010).

    Article  PubMed  Google Scholar 

  8. Chen, Z. et al. Immunity 51, 840–855 (2019).

    Article  PubMed  Google Scholar 

  9. Connolly, K. A. et al. Sci. Immunol. 6, eabg7836 (2021).

    Article  PubMed  Google Scholar 

  10. Utzschneider, D. T. et al. Immunity 45, 415–427 (2016).

    Article  PubMed  Google Scholar 

  11. Utzschneider, D. T. et al. Nature Immunol. 21, 1256–1266 (2020).

    Article  PubMed  Google Scholar 

Download references

Competing Interests

The authors declare no competing interests.

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