Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The origins of ovarian cancer

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Nature 600, S42-S44 (2021)


This article is part of Nature Outlook: Ovarian cancer, an editorially independent supplement produced with the financial support of third parties. About this content.

Updates & Corrections

  • Correction 01 February 2022: An earlier version of this article incorrectly attributed the theory that ovarian tumours might arise in the fallopian tubes and endometrium to Louis Dubeau. In fact, Dubeau suggested that some ovarian tumours might arise from epithelial cells with similar developmental origins, but did not identify the specific population of these cells within the fallopian tubes as the source.


  1. Kuchenbaecker, K. B. et al. JAMA 317, 2402–2416 (2017).

    Article  PubMed  Google Scholar 

  2. Spencer Wells, T. Med. Chir. Trans. 56, 113–128 (1873).

    Article  PubMed  Google Scholar 

  3. Dubeau, L. Gynecol. Oncol. 72, 437–442 (1999).

    Article  PubMed  Google Scholar 

  4. Piek, J. M. J. et al. J. Pathol. 195, 451–456 (2001).

    Article  PubMed  Google Scholar 

  5. Lee, Y. et al. J. Pathol. 211, 26–35 (2007).

    Article  PubMed  Google Scholar 

  6. Norquist, B. M. et al. Cancer 116, 5261–5271 (2010).

    Article  PubMed  Google Scholar 

  7. Perets, R. et al. Cancer Cell 24, 751–765 (2013).

    Article  PubMed  Google Scholar 

  8. Tone, A. A. et al. Clin. Cancer Res. 14, 4067–4078 (2008).

    Article  PubMed  Google Scholar 

  9. Przybycin, C. G., Kurman, R. J., Ronnett, B. M., Shih, I.-M. & Vang, R. Am. J. Surg. Pathol. 34, 1407–1416 (2010).

    Article  PubMed  Google Scholar 

  10. Steenbeek, M. P. et al. JAMA Oncol. 7, 1203–1212 (2021).

    Article  PubMed  Google Scholar 

  11. Toss, A. et al. Biomed. Res. Int. 2015, 341723 (2015).

    Article  PubMed  Google Scholar 

  12. Hanley, G. E. et al. Am. J. Obstet. Gynecol. 223, 221.e1–221.e11 (2020).

    Article  Google Scholar 

  13. Labidi-Galy, S. I. et al. Nature Commun. 8, 1093 (2017).

    Article  PubMed  Google Scholar 

  14. Cristiano, S. et al. Nature 570, 385–389 (2019).

    Article  PubMed  Google Scholar 

Download references


Nature Careers


  • Director for the Wisconsin National Primate Research Center

    The University of Wisconsin-Madison seeks a Director for the Wisconsin National Primate Research Center (WNPRC).

    Madison, Wisconsin

    University of Wisconsin-Madison Office of Vice Chancellor for Research

  • Postdoctoral Fellow

    New Orleans, Louisiana

    Tulane University School of Medicine

  • Assistant Professor

    The Department of Human Genetics at the University of Michigan Medical School (Ann Arbor, Michigan) seeks to fill two tenure-track faculty position...

    Ann Arbor, Michigan

    University of Michigan - Human Genetics

  • Assistant Professor Tenure-Track Faculty Position

    UGA seeks vibrant candidates for tenure-track Assistant Professor position in the Center for Molecular Medicine (CMM). Attractive startup package.

    Athens, Georgia

    Center for Molecular Medicine at the University of Georgia

  • Research Associate (Clinical Research)

    Houston, Texas (US)

    Baylor College of Medicine (BCM)

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing


Quick links