Cardiovascular diseases disrupt the bone-marrow niche

Itkin, Tomer; Rafii, Shahin

doi:10.1038/d41586-021-03550-y

NEWS AND VIEWS
23 December 2021

Cardiovascular diseases disrupt the bone-marrow niche

The production of blood cells, including some immune cells, relies heavily on the bone-marrow microenvironment. Cardiovascular diseases are now found to corrupt this niche, leading to imbalances in blood-cell production.

Tomer Itkin⁰ &
Shahin Rafii¹

Tomer Itkin
1. Tomer Itkin is in the Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, New York 10021, USA.
View author publications

You can also search for this author in PubMed Google Scholar
Shahin Rafii
1. Shahin Rafii is in the Division of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, New York 10021, USA.
View author publications

You can also search for this author in PubMed Google Scholar

Access through your institution

Buy or subscribe

According to the World Health Organization, cardiovascular diseases are the world’s leading cause of death (go.nature.com/3dvysp6). The development and progression of cardio-vascular disease (CVD) could be influenced by a perturbation in the balance of haematopoiesis, the process by which blood cells (including immune cells) are generated from haematopoietic stem and progenitor cells (HSPCs). Indeed, inflammatory blood cells that are derived from haematopoietic progenitor cells in the bone marrow have been implicated in cardiovascular disorders such as athero-sclerosis, a condition in which cholesterol builds up in the arteries; myo-cardial infarction (heart attack); and ischaemia, a form of heart failure that results from a lack of oxygen supply (reviewed in ref. 1). This relationship between the cardiac and haemato-poietic systems was thought to be unidirectional. However, writing in Nature Cardiovascular Research, Rohde et al.² provide evidence from individuals with CVD, as well as from mouse models of such disease, suggesting that the crosstalk between the cardio-vascular system and the bone marrow is bidirectional.

Access options

Access through your institution

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Nature 601, 515-517 (2022)

doi: https://doi.org/10.1038/d41586-021-03550-y

References

Poller, W. C., Nahrendorf, M. & Swirski, F. K. Circ. Res. 126, 1061–1085 (2020).
Article PubMed Google Scholar
Rohde, D. et al. Nature Cardiovasc. Res. 1, 28–44 (2022).
Article Google Scholar
Morrison, S. J. & Scadden, D. T. Nature 505, 327–334 (2014).
Article PubMed Google Scholar
Rafii, S., Butler, J. M. & Ding, B.-S. Nature 529, 316–325 (2016).
Article PubMed Google Scholar
Agarwala, S. & Tamplin, O. J. Trends Cell Biol. 28, 987–998 (2018).
Article PubMed Google Scholar
Yan, H., Baldridge, M. T. & King, K. Y. Blood 132, 559–564 (2018).
Article PubMed Google Scholar
Ferraro, F. et al. Sci. Transl. Med. 3, 104ra101 (2011).
Article PubMed Google Scholar
Hoffmann, J. et al. Nature Commun. 12, 3964 (2021).
Article PubMed Google Scholar
Kusumbe, A. P., Ramasamy, S. K. & Adams, R. H. Nature 507, 323–328 (2014).
Article PubMed Google Scholar
Baudino, T. A. et al. Genes Dev. 16, 2530–2543 (2002).
Article PubMed Google Scholar
Itkin, T. et al. Nature 532, 323–328 (2016).
Article PubMed Google Scholar
Lévesque, J.-P. et al. Stem Cells 25, 1954–1965 (2007).
Article PubMed Google Scholar
Hooper, A. T. et al. Cell Stem Cell 4, 263–274 (2009).
Article PubMed Google Scholar
Nolan, D. J. et al. Dev. Cell 26, 204–219 (2013).
Article PubMed Google Scholar
Dolgalev, I. & Tikhonova, A. N. Front. Cell Dev. Biol. 9, 622519 (2021).
Article PubMed Google Scholar
Han, X. et al. Cell Stem Cell 28, 1160–1176 (2021).
Article PubMed Google Scholar
Palikuqi, B. et al. Nature 585, 426–432 (2020).
Article PubMed Google Scholar