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Single-cell proteomics takes centre stage

Deducing the full protein complement of individual cells has long played second fiddle to transcriptomics. That’s about to change.
  1. Jeffrey M. Perkel
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Ying Zhu places a chip containing samples for analysis into the automated nanoPOTS system.

Chemist Ying Zhu places a nanoPOTS chip containing protein samples into an automated analysis system. Credit: Andrea Starr/PNNL

Claudia Ctortecka was both sceptical and intrigued when her thesis adviser told her in 2018 about a new method that uses mass spectrometry to analyse the protein contents of individual cells. When he said he was looking for someone to pursue this single-cell proteomics strategy in his laboratory at the Vienna BioCenter research institute, she decided to take a chance.

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Nature 597, 580-582 (2021)

doi: https://doi.org/10.1038/d41586-021-02530-6

Updates & Corrections

  • Correction 27 September 2021: This Technology feature omitted the citation for Erwin Schoof’s study. It should have cited E. M. Schoof et al. Nature Commun. 12, 3341 (2021) as reference 6, with subsequent citations renumbered.

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