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  • RESEARCH HIGHLIGHT

A CRISPR fix for muscles hatches from a viral shell

Scientists create millions of mutant viruses to find those that excel at ferrying genome-editing tools into muscle tissue.
Whole mount fluorescent images of quadriceps from 8-week-old C57BL/6J mice

Muscle from a mice injected with a standard viral shell (centre) takes up fewer viral particles than does muscle (right) injected with a viral shell called MyoAAV, as indicated by a fluorescent label. (The muscle on the left was injected with saline.) Credit: M. Tabebordbar et al./Cell

Targeting genome-editing tools to the right part of the body could become much easier thanks to delivery vehicles made from a viral protein shell1.

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Nature 597, 450 (2021)

doi: https://doi.org/10.1038/d41586-021-02508-4

References

  1. Tabebordbar, M. et al. Cell 184, 4919–4938 (2021).

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