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Mix-and-match COVID vaccines: the case is growing, but questions remain

A slew of studies suggests that mixing vaccines provokes potent immune responses, but scientists still want answers on real-world efficacy and rare side effects.
  1. Dyani Lewis

    1. Dyani Lewis is a freelance science journalist in Melbourne, Australia.

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Mixing COVID-19 vaccines is emerging as a good way to get people the protection they need when faced with safety concerns and unpredictable supplies. Most vaccines against SARS-CoV-2 must be given in two doses, but multiple studies now back up the idea that mixing the Oxford–AstraZeneca jab and the Pfizer–BioNTech vaccine triggers an immune response similar to — or even stronger than — two doses of either vaccine.

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Nature 595, 344-345 (2021)

doi: https://doi.org/10.1038/d41586-021-01805-2

References

  1. Liu, X. et al. Preprint at SSRN https://doi.org/10.2139/ssrn.3874014 (2021).

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  3. Schmidt, T. et al. Preprint at medRxiv https://doi.org/10.1101/2021.06.13.21258859 (2021).

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