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  • RESEARCH HIGHLIGHT

Meddling with RNA slicing cuts a tumour down to size

Experiments in mice show promise for drugs that modify the integral process called RNA splicing.
CD8 T cells from naïve C57BL/6 mice

Mouse T cells have a strong immune reaction (dark spots, bottom two rows) to unusual protein fragments generated by drugs that affect RNA splicing; T cells that are unexposed (top) or treated with a known antigen (second row) show a different pattern. Credit: Sydney X. Lu, Omar Abdel-Wahab and Robert K. Bradley

Drugs that alter how tumours’ RNA molecules are chopped up and stitched back together can enhance the effect of some cancer treatments, according to a study in mice.

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Nature 595, 10 (2021)

doi: https://doi.org/10.1038/d41586-021-01717-1

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